Pregnancy

Risky, the trophoblast biopsy?

Risky, the trophoblast biopsy?


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"My gynecologist has prescribed a trophoblast biopsy, is it less risky than amniocentesis?" Dr. François Devianne, gynecologist-obstetrician, answers Marine's question.

The answer of Dr. François Devianne, gynecologist-obstetrician, head of the maternity ward of the Orsay hospital.

  • Biopsy of the trophoblast, also called chorionic villus sampling, and amniocentesis are prenatal diagnostic tests (PND), used to establish a diagnosis of genetic, chromosomal or infectious abnormalities, such as cystic fibrosis, trisomy 21 or toxoplasmosis in the fetus.
  • While amniocentesis can not be performed before the 16th SA (weeks of amenorrhea), the trophoblast biopsy can be performed from the 11th SA.
  • If the first involves puncturing amniotic fluid, the second is based on the removal of placenta cells.
  • The biopsy of the trophoblast is performed earlier and delivers its results after 48 hours, compared with at least 15 days in most cases of amniocentesis. It has the advantage of being able to reassure parents more quickly. As in some situations, its results may be less accurate, they may need to be confirmed by amniocentesis, in order to make a definitive diagnosis.
  • Amniocentesis and trophoblast biopsy are tests that have a low risk of fetal loss, which can lead to miscarriage. This risk is from 0.5% to about 1%. Therefore, these two interventions are performed in aseptic conditions and optimal techniques as in the operating room and require a few days of rest.

Interview by Frédérique Odasso

Other expert answers.